Levings Lab Research Overview

Research in my laboratory is focused on a novel subset of CD4+ T cells, termed T regulatory (Treg) cells, which control immune homeostasis. Although we know that Treg cells have a fundamental role in regulating immunity to both self and foreign proteins, little is known about how they function. Current work is focused on determining how Treg cells differ from normal CD4+ T cells at both the biochemical and molecular levels, and elucidating their role in transplantation tolerance, cancer and inflammatory bowel disease. A long-term goal is to develop methods to generate Treg cells in vitro for use as a cellular therapy to replace standard immuno-suppression in the context of organ transplantation or to restore tolerance in the context of autoimmunity.

 

Specific projects currently on-going include:

  • Studying the unique cell-signalling pathways in human and mouse Tregs
  • Developing biomarkers to track the function of Tregs
  • Studying the interaction between Tregs and IL-17-producing cells
  • Studying tissue-derived Tregs from patients with graft versus host disease or inflammatory bowel disease
  • Developing methods to use Tregs as a cellular therapy in transplantation
  • Developing biomarkers to predict responses to therapy in inflammatory bowel disease

Links & Resources

iGenoMED Study Sample Collection Tutorial Videos

PART I: Preparing for Blood Collection 

This video is the first part of a two-part video tutorial for CRAs who are collecting the 50mL blood sample from iGenoMED Study patients. Part I describes what needs to be in place before blood collection.

PART II: Processing Blood for Plasma and Serum

This video is the second part of a two-part video tutorial for CRAs who are collecting the 50mL blood sample from iGenoMED Study patients. Part II describes the processing of blood into aliquots of plasma and serum.

Partnerships

The Levings Lab works closely with research groups and partners, such as: