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November 18, 2002
Researchers Identify Possible Cause of Rare Form of Breast Cancer in Children and Adults
(Vancouver)-A rare form of breast cancer found in children and adults appears to be the result of a novel protein that is created by a specific genetic change in tumour cells. According to a new study published in the November issue of Cancer Cell, this protein is linked to tumour growth in a subtype of human breast cancers called secretory breast carcinoma (SBC). Although SBC represents only 1% of all breast malignancies, it is thought to be related to the more prevalent form of breast cancer called ductal breast carcinoma.
"We have compelling evidence to suggest that the protein created by this genetic alteration, called ETV6-NTRK3, is actually causative in secretory breast carcinoma" says lead researcher Dr. Poul H. B. Sorensen of Children's and Women's Health Centre of B.C. "Until now the genetic causes of sporadic (non-hereditary) breast cancer have been too complex to determine the inciting events in tumour formation. The results of this study are the first to link a specific genetic alteration and a single protein abnormality to the formation of sporadic cancerous breast tumours. The identification of this protein means we will now be able to study ways to block its actions and potentially its formation."
"Our findings are a first step towards discovering new therapies for the treatment of breast cancer. We now have a better means of diagnosing SBC and developing treatments that are preferable to the strategies we use now," says Dr. Sorensen. "In the future we may be able to avoid the disfiguring surgery that causes so many difficulties for breast cancer survivors. We also feel that this study exemplifies how the study of childhood cancers can provide valuable information that is applicable to adult cancers."
The study was conducted by Dr. Sorenson's team over several years at the British Columbia Research Institute for Children's and Women's Health with participation from researchers in several countries.
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