• Tucker, Lori B.

    Titles
    Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Rheumatology, Department of Pediatrics, University of British Columbia
    Degrees / Designations
    MD
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2437
    Fax
    604-875-3141
    Lab Phone
    Mailing Address
    BC Children's Hospital
    Room K4-120, 4480 Oak Street
    Vancouver, BC V6H 3V4
    Affiliate Websites
    Research Areas
    • Predicting and improving outcomes for children and youth with chronic rheumatic diseases such as juvenile arthritis and systemic lupus erythematosus
    • Understanding the impact of chronic disease on children and families, using standardized questionnarires-methodology and correlation with clinical outcomes
    Summary
    My clinical research focus areas include prediction of outcomes for children with juvenile idiopathic arthritis and improving care through longitudinal outcomes registries,  study of physical activity in children with juvenile idiopathic arthritis, transition of youth with rheumatic disease to adult care, and translational research in autoinflammatory disease.   The strong partnerships of our Division of Pediatric Rheumatology as well as pan-Canadian collaborators in the Canadian Alliance for Pediatric Rheumatology Investigators fuel my research projects and ensure successful translation of research results to practice.  I have particular interest in creative knowledge translation in pediatric rheumatology research, and active inclusion of patients and families into research.
    Current Projects

    ReACCH-Out: Research on Arthritis in Canadian Children, Emphasizing Outcomes: a Canadian multi-centre collaborative outcomes study
    I am one of four principal investigators for this seminal CIHR-funded NET project, in which our pediatric rheumatology research program in Canada enrolled 1,500 newly diagnosed children with JIA into a longitudinal registry. This project has resulted in 6 publications to date and a number more in preparation, and is providing us with important data demonstrating the trajectory of JIA using modern treatments, prediction of disease course using disease features from early in disease, evaluation of pain over the course of JIA, incidence and prevalence of JIA-associated uveitis, as well as other areas of research. This project has provided the infrastructure to allow CAPRI to obtain funding and move forward to establish a long-lasting Canadian JIA registry.

    LEAP: Linking Exercise, Activity and Pathophysiology in Canadian Children with Arthritis: A Pan-Canadian Team:
    I am a co-nominated Principal Investigator on this pan-Canadian project studying physical activity in children with JIA. Our project aims are to study the determinants of physical activity in children with JIA, to examine variables that predict PA in these patients, and to determine how PA influences clinical outcomes, inflammatory biomarkers, and the development of bone and muscle in children with JIA. The project involves 12 pediatric rheumatology centres across Canada and we have enrolled nearly 500 children and youth with JIA into a 2 year longitudinal study, looking at their level of PA over time as well as clinical, inflammatory, bone and muscle parameters. In addition, we are performing a novel pilot exercise intervention study, looking at new ways to encourage increased targeted activity in children with JIA that is safe and effective as well as fun.

    Promoting successful transition from pediatric rheumatology care to adult care for youth with chronic rheumatic diseases:
    I am a collaborator on several projects aimed at development and testing of transition resources for youth and younger children with JIA or other rheumatic diseases. Our research group is currently doing a randomized controlled trial of a youth on line self management website called Teens Taking Charge, aimed at youth with JIA. We are in the development phase for a similar self management program for younger children with JIA and their parents. We are also starting final testing of a transition questionnaire called RACER (Readiness for Adult Care in Rheumatology), which will be tested in a number of Canadian pediatric rheumatology centres.

    Pediatric Autoinflammatory Research Consortium (PARC):
    I am the co-leader of the PARC initiative with Dr. Kelly Brown. In this developing research program, we aim to establish a Canada-wide registry for children and youth with rare auto-inflammatory disease, linked to a biorespository, and to initiate a translational science research program to understand the basis for autoinflammation in these patients. Many children with autoinflammatory disease characteristics do not have an identified disorder, and may have a novel monogenic, or novel complex gene disorder. Understanding the basis for these rare diseases will provide new directions for effective treatments, as well as an improved understanding of the basis for episodic inflammatory conditions overall.

    Selected Publications

    Mina R, Klein-Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, Onel K, Tucker L, O'Neil KM, Punaro M, Levy DM, Haines K, Martini A, Ruperto N, Lovell D, Brunner HI. Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus. Ann Rheum Dis. 2014 Feb 1;73(2):401-6. PMID: 23345596.

    Levy DM, Peschken CA, Tucker LB, Chedeville G, Huber AM, Pope JE, Canadian Network for Improved Outcomes in SLE (CaNIOS), Silverman E. Health related quality of life in childhood-onset systemic lupus erythematosus is associated with ethnicity: Results from a multiethnic multicenter Canadian cohort. Arthritis Care Res. 2014 May 12. PMID: 24821613.

    Guzman J, Oen K, Tucker LB, Huber AM, Shiff N, Boire G, Scuccimarri R, Berard R, Tse SM, Morishita K, Stringer E, Johnson N, Levy DM, Duffy KW, Cabral DA, Rosenberg AM, Larche M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey S, Bruns A, Campillo S, Benseler S, Schneider R, Yeung R, Duffy CM. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort. Ann Rheum Dis. 2014 May 19. Annrheumdis-2014-205372. PMID: 24842571.

    Shiff NJ, Lix LM, Oen K, Joseph L, Duffy C, Stringer E, Tucker LB, Svenson LW, Belisle P, Bernatsky S. Chronic inflammatory arthritis prevalence estimates for children and adolescents in three Canadian provinces. Rheumatol Int. 2014 Jul 15. PMID: 25023756.

    Jetha A, Badley E, Beaton D, Fortin PR, Shiff NJ, Rosenberg AM, Tucker LB, Mosher DP, Gignac MA. Transitioning to employment with a rheumatic disease: The role of independence, overprotection, and social support. J Rheumatol. 2015: 35(2):345-350. PMID: 25274887.

    Eng Sw, Duong TT, Rosenberg AM, Morris Q, Yeung RS, ReACCH Out and BBOP Research Consortia. The biologic basis of clinical heterogeneity in juvenile idiopathic arthritis. Arthritis Rheumatol. 2014 Dec;66(12): 3463-75. PMID: 25200124.

    Shiff NJ, Abdwani R, Cabral DA, Houghton KM, Malleson PN, Petty RE, Espinosa VM, Tucker LB.: Access to pediatric rheumatology subspecialty care in British Columbia, Canada. J Rheumatol. 2009 Feb;36(2):410-5. PMID: 19132779.

    Suzuki M, Wiers K, Brooks EB, Greis KD, Haines K, Klein-Gitelman MS, Olson J, Onel K, Oʼneil KM, Silverman ED, Tucker L, Ying J, Devarajan P, Brunner HI. Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis. Pediatr Res. 2009 Feb 11. [Epub ahead of print] PubMed PMID: 19218887.

    Shiff NJ, Abdwani R, Cabral DA, Houghton KM, Malleson PN, Petty RE, Espinosa VM, Tucker LB. Access to pediatric rheumatology subspecialty care in British Columbia, Canada. J Rheumatol. 2009 Feb;36(2):410-5. PubMed PMID: 19132779.

    Brunner HI, Klein-Gitelman MS, Ying J, Tucker LB, Silverman ED.: Corticosteroid se in childhood-onset systemic lupus erythematosus-practice patterns at four pediatric rheumatology centers. Clin Exp Rheumatol. 2009 Jan-Feb;27(1):155-62. PMID: 19327245.

    Grants
    Honours & Awards
    Research Group Members
    Angelyne Sarmiento- Research Manager, Pediatric Rheumatology
    Felice Mirzan- Research Manager, Pediatric Rheumatology