• Pritchard, Sheila

    Titles
    Investigator, BC Children's Hospital
    Clinical Associate Professor, Division of Hematology and Oncology, Department of Pediatrics, University of British Columbia
    Degrees / Designations
    BMedSci, BM, BS
    Primary Area of Research
    Childhood Diseases
    Secondary Area(s) of Research
    Phone
    604-875-2644
    Fax
    604-875-2911
    Lab Phone
    Mailing Address
    Division of Oncology/Hematology/BMT
    BC Children's Hospital and BC Women's Hospital & Health Centre
    Room A123D, 4480 Oak Street
    Vancouver, BC V6H 3V4
    Affiliate Websites
    Research Areas
    • Late effects of childhood cancer
    • Survivor studies
    • Anthracycline cardiomyopathy
    • Outreach management
    Summary

    My primary interest lies in both the clinical and research aspects of long-term follow up in survivors of childhood cancer.  Enormous strides have been made in childhood cancer treatments but not without cost to the patients and their families.  Some of the ramifications of these advances are immediate while others are more insidious, stretching into adulthood, and are just as devastating.

    In addition, the impact of childhood cancer on patients and their families demands that we take this opportunity to examine the complex interrelationships relevant to the psychological well-being of these children's caregivers.

    In association with widely respected researchers and, in a combination of clinical and epidemiological research endeavours, our vision is to clarify and translate these results into meaningful practice and better define health care resource availability.

    Current Projects

    BC childhood adolescent & young adult cancer survivorship research program
    In this program we will attempt to identify a survivor cohort and a comparison group with a view to developing a database for both surveillance and research in this group of patients.  Additionally, we propose to assess the impact of childhood cancer and its treatment on late effects and educational outcomes. Through examining treatment modalities and the subsequent resource use we propose development of essential tools to translate and transfer research results to policy makers and care providers with the aim of building capacity for collaborative research.

    Parents of children with cancer - a study of factors related to their physical and psychological well-being
    Childhood cancer is a life-threatening disease - its onset is often acute, its treatment is intensive and demanding and may extend for several years.  A diagnosis of childhood cancer with its associated range of short- and long-term adverse effects is a source of extreme stress for parents. High levels of parental distress have been found in many studies at diagnosis and during active treatment and remission. However, not all parents of children with cancer show high levels of distress. There is considerable variation within and between studies, and the relationship between childhood cancer (the stressor) and parental physical and psychological well-being is not clear.  This study will contribute to this understanding, and will be an important step towards improving services to families of children with cancer.

    A questionnaire-based review of long-term follow-up programs for survivors of childhood cancer in Canada
    It is felt that long-term follow-up programs of childhood cancer survivors vary considerably in size, in the availability of specialty services, in funding sources and in their accessibility.  This study is to determine where long-term follow-up programs are available for the survivors of childhood cancer and to determine the extent of services that are offered.

    Selected Publications
    Sung L, Klaassen RJ, Dix D, Pritchard S, Yanofsky R, Dzolganovski B, et al.: Identification of paediatric cancer patients with poor quality of life. Br J Cancer. 2009 Jan 13;100(1):82-88.

    Guilcher GM, Fitzgerald C, Pritchard S.: A questionnaire based review of long-term follow-up programs for survivors of childhood cancer in Canada. Pediatr Blood Cancer. 2009 Jan;52(1):113-115.

    Klassen AF, Klaassen R, Dix D, Pritchard S, Yanofsky R, O'Donnell M, Scott A, Sung L.: Impact of caring for a child with cancer on parents' health-related quality of life. J Clin Oncol. 2008 Dec 20;26(36):5884-9.

    Bond M, Pritchard S. Understanding Clinical Trials in Pediatric Cancer. Pediatrics and Child Health. 2006; 11(3):148-50.

    Wasan KM, Wong JC, Corr T, Pritchard S.  Role of plasma lipids and lipoproteins in predicting amphotericin B-induced nephrotoxicity in pediatric oncology patients.  Cancer Chemother Pharmacol 2006 Jan; 57(1):120-124.

    Hewitt J, Ballard JN, Nelson TN, Smith VC, Griffiths TA, Pritchard S, Wu JK, Wadsworth LD, Casey B, & MacGillivray RT. (2005) Confirmation of Paternity Suggests a New Mutation in the Factor VII Gene: 'Pater Certus Quouque Est.'  Br J Haematol 2005; 130:458-464.

    Hewitt J, Ballard JNM, Nelson TN, Smith VC, Griffiths TAM, Pritchard S, Wu JK, Wadsworth LD, Casey B, MacGillivray RTA.  Severe Factor VII deficiency caused by a new point mutation combined with a previously undetected gene deletion.  Br J Haematol 2005 Feb; 128(3):380-385.

    Jastaniah WA, Pritchard SL, Wu JK, Wadsworth LD.  Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children.  American Society for Clinical Pathology 2004 Dec; 122:849-854.

    Alessandri AJ, Pritchard SL, Schultz KR, Massing BG.  A population-based study of pediatric anaplastic large cell lymphoma. Cancer 2002 Mar 15; 94(6):1830-5.

    Pashankar FD, Steinbok P, Blair G, Pritchard S.  Successful Chemotherapeutic decompression of primary endodermal sinus tumor presenting with severe spinal cord compression.  J Pediatr Hematol Oncol 2001 Mar-Apr; 23(3):170-3.

    Grants
    Honours & Awards

    R. Samuel McLaughlin Fellowship, awarded to the most promising resident in any specialty at each Canadian university - 1984-1985

    Research Group Members
    Nita Takeuchi - Senior clinical research associate
    Colleen Fitzgerald - Clinical research manager